RNA–ligand interactions • Protein–ligand interactions • Structure-based ligand design
My current research focuses on developing integrated experimental and computational frameworks that transform RNA‑ligand discovery from isolated successes into scalable and reproducible biophysics‑driven pipelines. By combining high‑throughput biophysics, RNA structural mapping, and structure‑enabled virtual screening, my work enables systematic interrogation of challenging therapeutic targets relevant to infectious diseases, antimicrobial resistance, and rare genetic disorders.
My goal is to integrate chemical biology, biophysics, structural biology and computational biology to address unmet and difficult therapeutic challenges to support patients. My main focus remains on infectious diseases and rare genetic disorders. For infectious diseases, I aim to employ comprehensive strategies to identify novel antibacterial agents, with a particular focus on under‑explored protein and RNA targets.
Rare genetic diseases are under-recognised worldwide, including in India, and some become life‑threatening due to delayed or missed diagnosis. I aim to explore the fundamental molecular pathways to identify biochemical biomarkers of disease states and then engineer sensitive diagnostic tools leveraging microfluidics and molecular recognition strategies.